1054 GENDER DIFFERENCES IN MINOCA POPULATION

Abstract Background Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) is a clinical condition that includes acute myocardial infarction (AMI) occurring non-obstructive coronary disease. This entity accounts above 6% (from 1% to 14%) of all patients presenting AMI and it's known be more prevalent in females. However, differences terms features prognosis MINOCA according gender have been poorly understood. Purpose To evaluate characteristics at admission during follow-up between males females MINOCA. Methods We included consecutive undergoing angiogram 2016 2020 our center. According ESC Position Paper criteria, we considered as stenosis <50% angiography without clinically apparent alternative diagnoses such Takotsubo syndrome myocarditis. Then, analyzed the baseline by dividing population into two groups gender. Variables statistical significance lower than p<0.05 univariable analysis were logistic regression determine independent predictors The predictive value both was evaluated using Kaplan-Meier survival curves. Our aim composite endpoint death, re IMA, stroke heart failure follow up time mean 36 ± 14.8 months. Results Among 289 affected 98 male (34%) 191 female (66%). Females older (68.9 13.1 vs 58.4 14.5 years, p =0.0001). About traditional cardiovascular risk factors frequently smokers (56.1% 33.9%, p=0.001) while there no significant others factors. on beta-blockers (39% 20%, p=0.002) statins (33% 19%, p=0.015) compared males. No found regarding instrumental findings (EKG echocardiography). At angiography, had severe (15.5 26.4 VS 9.1 21.5, =0.019). During did not find any reinfarction, MACEs 19.4%, p=0.015); this data confirmed Kaplan Meier curves (p = 0.014). Finally, multivariate showed age an predictor (HR 1.04, CI 1.01-2.07, p=0.006), rather sex, diabetes, hypertension. Conclusions In males, beta blockers they degree atherosclerotic Nevertheless, after months follow-up, higher incidence MACE hypothesize these could reflect different pathogenesis damage subgroups. Actually, estrogens well-known protective role towards progression atherosclerosis, but impact other mechanisms which are frequent females, spontaneous artery dissections, epicardial spasms or microvascular dysfunction.